Abstract
Parachloromercuribenzenesulphonic acid (PCMBS), an agent which increases passive permeability of cations by reacting with sulfhydryl groups of the membrane, much less increases cation permeability in hereditary spherocytic (HS) red cells than normal red cells. Pronase which is thought to alterate the charged amino groups of the membrane, changes permeability of cations in the same degree with normal and HS red cells. Alteration of sulfhydryl groups of the membrane may be primarily involved in the changes of cation permeability in HS red cells.
