抄録
Changes in the arylsulfatase (AS) activity in the brain were detected in the experimental allergic encephalomyelitis (EAE) using ascorbate-2-sulfate (AAS) as a natural substrate for AS-A. Catecholamine (CA) levels in the brain in EAE rats were also detected.
It was found as the results that
1) AS-A hydrolyzing a natural substrate AAS, was not different in the EAE rats from the normal ones.
2) Total AS hydrolyzing a synthetic substrate, 4-methylumbelliferyl sulfate (4-MUS), increased after EAE indction.
3) Only norepinephrine (NE) level among CA levels of the brain in the EAE rats was specifically lower.
4) It may be assumed that only AS-B incrases in the EAE rats, and the disturbance of nor-adrenargic nervous functions can be ascribable to these phenomena.
