Studies on Screening Test for Urine of Workers Exposed to Organic Solvent Products Such as Thinners.

Abstract

We describe a high performance Liquid chromatographic method for the screening test of hippuric acid and o-, m-and p-methylhippuric acids in urine, metabolites of toluene, o-, m- and p-xylenes, respectively. The method has simple, specific and high sensitivity. All the Metabolites were clearly separated in a short time. Methylhippuric acids could not be detected in the normal urine by this method, even if it contains high concentration of hippuric acid. The present method can be used for the health control of workers exposed to organic solvent products such as thinners.