Clinical Evaluation of Superoxide Dismutase Activity, Lipid Peroxide and Ceruloplasmin in Serum and Synovial Fluid of Patients with Rheumatoid Arthritis

Abstract

The levels of superoxide dismutase (SOD), lipid peroxide (LPO) and ceruloplasmin in sera and synovial fluids were determined in rheumatid arthritis (RA), osteoarthritis (OA) and infectious arthritis (IA),
Total SOD, Cu, Zn-SOD activity and LPO level in synovial fluid from patients with RA and IA were found to be remakably higher than from OA, hower, Mn-SOD activity showed no difference.
The SOD activity in serum from RA was singnificantly lower than OA, but the LPO value Showed no difference.
Ceruloplasmin levels were increased in serum and synovial fluid from RA.
These results suggest that synovial fluid measurment may be useful in clinical evaluation of chronic inflammatory disorders.