抄録
The ketone body ratio in the blood, the ratio of acetoacetic acid to 3-hydroxybutyric acid, reflecting the energy charge in hepatic mitochondria, is an indicator of hepatic functional reserve in chronic liver injury. In the present study, changes in the ketone body ratio in the blood were determined in rats with acute and subacute choiestatic liver injury induced with α-naphthylisothiocyanate (ANIT). The ketone body ratio in the blood was significantly increased 12-60 hours after a single administration of ANIT. When the dose of ANIT was increased to 50-200 mg Per kg of body weight, the ratio was linearly increased. When ANIT was administered for 15 consecutive days, the ratio was increased to twice that of the control after 6 days of administration and remained the same until the 15th day. Thus, in acute and subacute cholestatic liver injury, the ketone body ratio showed a compensatory increase uniike the case for chronic liver injury.
