Action of Dilazep Dihydrochloride on Chemiluminescence from a Xanthine Oxidase/Acetaldehyde System

Yasunobu Yoshinaka; Toru Yokoyama; Masaki Nakamura

doi:10.14921/jscc1971b.19.4_350

Japanese Journal of Clinical Chemistry

Online ISSN : 2187-4077
Print ISSN : 0370-5633
ISSN-L : 0370-5633

Action of Dilazep Dihydrochloride on Chemiluminescence from a Xanthine Oxidase/Acetaldehyde System

Yasunobu Yoshinaka, Toru Yokoyama, Masaki Nakamura

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Keywords: dilazep, chemiluminescence, xanthine oxidase, radical scavenger

JOURNAL FREE ACCESS

1990 Volume 19 Issue 4 Pages 350-353

DOI https://doi.org/10.14921/jscc1971b.19.4_350

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Abstract

Superoxide dismutase ISOD), catalase, hydroxyl radical (OH) scavengers and singlet oxygen (¹O₂) quenchers suppress the light signal from a xanthine oxidase/acetaldehyde system. Xanthine oxidase inhibitor allopurinol also suppresses the light signal from the system. Dilazep HCl (10^-5-10^-3M) suppresses the chemiluminescence in a concentration dependent manner without affecting the xanthine oxidase activity. These results suggest that dilazep exhibits a radical scavenger-like action.

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