Unexpected Presence of Delta Bilirubin in the Serum of a Patient with Type I Crigler-Najjar Syndrome Observed by a Kodak Ektachem 700N Analyzer

抄録

Serum bilirubin concentration in a patient with type I Crigler-Najjar syndrome (CNJ) was determined by means of a Kodak Ektachem 700N analyzer, and a questionable presence of delta bilirubin (Bd) was observed. HPLC was used to ascertain whether or not the derived Bd concentration was artifactual. Total bilirubin concentration in the patient was correctly evaluated by the Ektachem method, whereas the measured unconjugated bilirubin was underestimated as compared with that obtained by the HPLC method. Therefore, a questionable Bd value, derived from these results, was observed.