尿中ジペプチジル-アミノペプチダーゼIV X-プロリルジペプチジル-アミノペプチダーゼ活性の腎疾患における変化

加藤 武; 浜 登希子; 小島 幸一; 永津 俊治; 榊原 俊平; 吉井 才司; 武市 政之; 川合 秀男

doi:10.14921/jscc1971b.8.1_131

Changes in Urinary Activity of Dipeptidyl-Aminopeptidase IV

X-Prolyl Dipeptidyl-Aminopeptidase in Renal Diseases

TAKESHI KATO, TOKIKO HAMA, KOHICHI KOJIMA, TOSHIHARU NAGATSU, SHUMPEI SAKAKIBARA, SAIJI YOSHII, MASAYUKI TAKEICHI, HIDEO KAWAI

Author information

TAKESHI KATO
Laboratory of Cell Physiology, Department of life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
TOKIKO HAMA
Laboratory of Cell Physiology, Department of life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
KOHICHI KOJIMA
Laboratory of Cell Physiology, Department of life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
TOSHIHARU NAGATSU
Laboratory of Cell Physiology, Department of life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology
SHUMPEI SAKAKIBARA
Peptide Institute, Protein Research Foundation
SAIJI YOSHII
1st Department of Internal Medicine, Nagoya University School of Medicine
MASAYUKI TAKEICHI
Kamo Hosupital
HIDEO KAWAI
Kamo Hosupital

JOURNAL FREE ACCESS

1979 Volume 8 Issue 1 Pages 131-134

DOI https://doi.org/10.14921/jscc1971b.8.1_131

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Abstract

A new fluorometric method for determination of the activity of urinary dipe-ptidyl-aminopeptidase IV (X-prolyl dipeptidyl-aminopeptidase) was applied to the assay of the enzyme in the urine from patients with renal diseases. It was possible to use urine from patients directly without any preliminary isolation procedures. The urinary enzyme activity was found to be elevated in some patients with chronic glomerulonephritis and nephrotic syndrom.

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