1992 Volume 15 Issue 2 Pages 201-207
A 9 years old girl, in whom both motor and mental activities were found to be deteriorated since the patient was 7 years old, was diagnosed as subacute sclerosing panencephalitis (SSPE). Clinical signs and symptoms were consisted with regression, myoclonic movement of extremities, periodic synchronous dischange (SSPE complex) in EEG. Antimeasles antibody was detected with high titers in both serum and CSF. She has been treated with combination of anticonvulsants, inosiplex, intrathecal injection of recombinant interleukin-2 (rIL-2) and intravenous injection of high dose glycyrrhizin. She showed a sign of recovring in speaking ability and relieved from frequent myoclonus. Several immunological abnormalities including reversed CD 4/CD 8 ratio, negative delayed type hypersensitivity skin test, low natural killer cell activity and poor ability of IFN-γ production were noticed. Those abnormalities have been recovered to normal lebels following clinical improvement after the treatment.
