Serum Elevated Levels of Total Antioxidant Power, a biomarker of physiological response to oxidative stress, Correlate with Renal Vascular Damage in Patients with Systemic Sclerosis

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Purpose: Oxidative stress is important factor that contribute to tissue damage in systemic sclerosis (SSc). Since the physiological response to oxidative stress is regulated by multiple antioxidant systems, it is important to quantitatively measure the total antioxidant capacity in the biological specimens. To determine the clinical significance of total antioxidant power (TAP) in SSc, we investigated the prevalence and clinical correlation of total antioxidant power levels in SSc patients by colorimetric microplate assay. Results: Serum TAP levels were significantly elevated in SSc patients compared to normal controls (p=0.003). TAP levels were correlated positively with systolic blood pressure (p<0.01) and plasma renin activity (p=0.01). In addition, TAP levels were correlated positively with renal vascular resistance (p<0.01) and negatively with renogram (p<0.01). TAP levels did not significantly correlate with mTSS, the extent of pulmonary fibrosis, and CRP levels.Conclusion: These results suggest that oxidative stress contributes to renal vascular damage associated with SSc and that TAP could be served as a useful marker for monitoring renal vascular injury in SSc.