Abstract
Nifedipine, a calcium antagonist, has been used as a treatment for hypertension.
We investigated the effects of food on blood concentration changes of nifedipine from the data of the bioequivalence study (BE study), using the package insert or interview form of nifedipine sustained-release preparations.
Regarding the changes in blood concentrations of nifedipine L tablets, a significant increase in AUC and a significant increase in Cmax were observed in all generic drugs when taken internally after meals compared to fasting administration.
In addition, changes in blood concentrations of nifedipine CR tablets were also observed to increase AUC and Cmax when taken orally after meals compared to fasting.
These rates of increase varied among generic drugs, and were thought to be affected by differences in the content and amount of meals in the BE study.
In nifedipine sustained-release preparations the increase in blood concentration of nifedipine due to the effect of dietary intake may enhance the antihypertensive effect.
When dispensing drugs with out-of-hospital prescriptions, pharmacists should give consideration to the selection of generic drugs and provide medication guidance that takes into account the patient's dietary style.
