シンポジウム17 ここまでわかった口腔細菌による全身疾患：最新の研究と臨床知見
４． 脳卒中患者における特定口腔細菌の検出と病態の関連性
2011 年 42 巻 2 号 p. 71-72
詳細
2011 年 42 巻 2 号 p. 71-72
Oral pathogens are indigenous microorganisms and can cause bacteremia easily by tooth brushing or dental extraction. Some of them carry the pathogen Streptococcus mutans (S. mutans) with a collagen-binding protein, named Cnm, which inhibits platelet aggregation. Under permission of our ethical committee, we studied whether such S. mutans is a risk factor for stroke. From February 16 to October 6, 2010, 167 serial patients with intracerebral hemorrhage (ICH) or cerebral infarction were admitted to our stroke care center. With written informed consent, we cultured their saliva and the results were compared with those of 37 healthy volunteers. Cultured rate of all S. mutans showed no statistically significant difference, however, the incidences of Cnm positive S. mutans were significantly high in patients with ICH and cerebral embolism from cardiac origin (p 0.0073 and 0.0069 respectively (Fisher's test) ). Roughly more than 10 percent of Japanese people have Cnm positive S. mutans in their oral cavities. Cnm positive S. mutans may be a new risk factor of stroke and further study is necessary.
