抄録
The effects of a hypotensor, indapamide, on diuresis, urinary excretion of electrolytes and cardiohemodynamics were compared clinico-pharmacologically with those of trichlormethiazide by a cross-over method in 7 male adult volunteers indicating borderline hypertension. Indapamide and trichlormethiazide were administered orally for 2 consecutive weeks each in doses of 2 and.4 mg once a day respectively. The day before the initiation of each medication was designed as control observation day. The effect on cardiohemodynamics was evaluated by measuring the blood pressure, pulse rate, cardiac index, stroke index and systemic vascular resistance before and after isometric exercise. The differences for 24-hr urine volume and 24-hr urinary electrolytes excretion were not statistically significant between both drugs. However, the onset of action was slower in indapamide than in trichlormethiazide, and the peak diuretic and electrolyte excretory activities of the former were also weaker than those of the latter. On the other hand, both actions of the former persisted longer than those of the latter. The blood pressure tended to lower 2 weeks after starting each medication. The cardiac and stroke indexes decreased significantly 2 weeks later, and the decrease lasted longer in indapamide group than in trichlormethiazide one.
