経口吸着剤としての活性炭ビーズおよびケイキサレートビーズの検討

Quinidineの吸収阻止

抄録

Beads were prepared from a cation exchange resin by a method similar to that for prepration of activated carbon beads. In an in vitro adsorption test using quinidine as a cationic drug, no reduction of the adsorbing capacities of activated carbon or of cation exchange resin was observed by incorporation into agar beads. The adsorbing capacity of cation exchange resin for quinidine tended to decrease in the presence of sodium chloride and saline purgatives such as sodium sulfate and magnesium sulfate, whereas that of activated carbon was slightly increased in the presence of the salts.
In a human study, both activated carbon beads and cation exchange resin beads taken at 20 min after administration of quinidine effectively reduced absorption of quinidine without significant difference in the degree of reduction.