抄録
Effects of Diazepam on conditioned continuous avoidance response (CAR), conditioned discriminated avoidance response (DAR) and conditioned suppression (Estes-Skinner procedure) were investigated. As the diazepam preparations, Cercine Injection and Cercine Tablet (Takeda Pharmaceutical Co. ) were used.
The potencies of diazepam effect varied according to the preparations and administration routes. 4.0-8.0 mg/kg of the injectable solution (Cercine Injection) given subcutaneously or intraperitoneally depressed the respondings in both CAR and DAR with a corresponding increase in the number of shock delivered. On the other hand, the same degree of this effect was obtained in the doses of 20.0-40.0 mg/kg of suspended solution of the tablet (Cercine Tablet) given orally.
Subcutaneous injection of 0.5-1.0 mg/kg selectively attenuated the conditioned suppression, but more than 2.0 mg/kg depressed even general responding. While 2.0 mg/kg of the tablet-suspension given orally was ineffective to attenuate the suppression, 10.0 mg/kg produced the same degree of the effect as 1.0 mg/kg given subcutaneously. Accordingly, when diazepam was administered subcutaneously or intraperitoneally, the effect was approximately 5-10 times potent independent of the schedules used, when compared with the oral administration.
The injectable preparation given orally showed the maximum effect much faster than the suspended solution of the tablet given in the same route, but the duration tended to be shorter.
