抄録
A new patient-side immunoassay system, Biotrack Theophylline®, was evaluated and compared with the widely-used monitoring analysis methods, enzyme-multiplied immunoassay (EMIT®) and fluorescence polarization immunoassay (TDx®). Blood samples were obtained from five healthy subjects who received oral multiple doses of aminophylline for three days. The theophylline concentrations obtained by Biotrack Theophylline correlated well with those by EMIT (r=0.974) and TDx (r=0.982), respectively. A good correlation was also observed between EMIT and TDx (r=0.986). The mean (±2standard deviation) discrepancy between two methods was as follows: EMIT-Biotrack: -0.23±14.93μmol/L, TDx-Biotrack: -4.83±11.96μmol/L, TDx-EMIT: -4.52±15.01μmol/L. These results indicate that Biotrack Theophylline is a reliable method for the therapeutic monitoring of theophylline by immediate determination of the drug concentration.
