話題提供
イヌの脈絡膜壁紙病変と化合物の構造活性相関
1991 年 10 巻 1-2 号 p. 1-2_49-1-2_53
詳細
1991 年 10 巻 1-2 号 p. 1-2_49-1-2_53
To investigate the relationships between the tapetal discoloration and chemical structure activity, beagle dogs were given a single intravenous administration of metabolites or analogs of a synthesized chymotrypsin inhibitor, FK-401.
The alcoholic metabolite of FK-401 caused discoloration in the tapetum lucidum. Numerous alcoholic analogs with a tertiary amine side chain also caused tapetal discoloring. However, no histopathological changes were observed in the tapetum layer. Ethambutol had a similar action.
These results suggested that some alcoholic compounds with a tertiary amine could induce discoloration of the tapetum lucidum in the canine eye.
