第17回 日本心電学会サテライト国際シンポジウム

抄録

We investigated the effects of short period (60 min) of rapid atrial pacing and sustained atrial fibrillation (At) induced by rapid atrial pacing on right atrial monophasic action potential duration (MAPD) and effective refractory period (ERP) and its rate adaptation in the dog. Short period of rapid atrial pacing leads to diminution of rate adaptation of MAPD and appearance of MAPD alternans at longer cycle length (CL) . Sustained Af leads to electrical remodeling with shorter MAPD, loss of rate-adaptation of MAPD and MAPD alternans at longer CL. Induction of Af in sustained Af (1/8 in control vs 8/8 in sustained At) was always preceded by the alternans of MAPD. Changes in MAPD restitution may also contribute to the initiation of Af.