第17回 日本心電学会サテライト国際シンポジウム
Tetsunori Saikawa, Tatsuhiko Ooie, Tomoko Nawata, Naohiko Takahashi, Masaya Arikawa, Masahide Hara, Toshiie Sakata
著者情報
2000 年 20 巻 Suppl3 号 p. 84-87
詳細
2000 年 20 巻 Suppl3 号 p. 84-87
The effects of ischemia-reperfusion insult on the arrhythmias and cardiac function were investigated in both control and diabetic rats. Rats were made diabetic by injection of streptozotocin 65mg/kg at 10-week of age and kept subsequent 12 weeks for later study. Both ventricular tachycardia and ventricular fibrillation were less during reperfusion in diabetic rats than in controls. The recovery of left ventricular developed pressure was also better in diabetic rats than in controls. Glibenclamide aggravated the ventricular tachycardia but not fibrillation when administered acutely. The application of staurosporin abolished protective effects noted in diabetic rats. In conclusion, the diabetic rats showed less ventricular arrhythmias and improved functional recovery, which were dissipated by staurosporm.
