2016 年 61 巻 4 号 p. 301-309
In our previous study (Sato et al., 2015), we calculated the storage capacity of subcutaneous fat area (SFA) accumulation from the cross-sectional approach. The present study aimed to determine the relationships between this storage capacity of SFA, the existing metabolic syndrome (MS) criteria, and cell biological scientific findings obtained from Sugihara’s study. Participants were 1354 Japanese adults. The relationships between the existing MS criteria [visceral fat area (VFA) cut-off point of 100 cm2] and our predicted storage capacity of SFA and VFA (SFAcap and VFAcal) were investigated by cross-tabulation. The percentage of participants with SFA > SFAcap and VFA > 100 cm2 was higher in males, whereas that of participants with SFA > SFAcap and VFA <100 cm2 was higher in females. To determine the cell biological characteristics of the SFAcap, mean values of SFA, VFA, and waist circumference (WC) were calculated for several BMI levels; these BMI levels provide an estimation of hypertrophy and hyperplasia of fat cells (Sugihara et al., 2006). The predicted SFAcap and VFAcal values were almost equal to their corresponding SFA and VFA values in the group wherein BMI ranged from 25 to 27. This BMI level corresponds to a stage in the"hypertrophy predominant"obesity type; in this stage, the cell shape of fat cells transitions from round to squamous. This result suggests that storage capacity of subcutaneous fat accumulation appears with a limitation of hypertrophy of fat cells.