抄録
Caloric responses were examined in four patients treated with SM sulfate repeatedly. In three patients, the caloric responses were reduced unilaterally or bilaterally during the first SM treatment and these responses recovered after cessation of SM sulfate administration. A second course of SM therapy was given to these patients. The caloric responses were immediately reduced again. The caloric response in the fourth patient did not change during the first and second course of SM therapy. Audiological examination showed minimal changes in these patients during SM therapy.
These results suggest that the caloric response during a second course of SM therapy is easily reduced in those patients whose caloric response is reduced during the first course. Examination of the caloric response is useful in the monitoring of patient for the prevention of SM ototoxicity.
