抄録
This paper summarizes the results of toxicity studies of 2,3,3,3-tetrafluoroprop-1-ene（HFO-1234yf）, which has been developed as a refrigerant for the next generation, and the developmental toxicity of hydrofluorocarbons （HFCs）, including 1,1,1,2,2-pentafluoroethane （HFC-125）, 1,1,1,2-tetrafluoroethane （HFC-134a）, 1,1,1-trifluoroethane （HFC- 143a）, 1,1-difluoroethane （HFC-152a）, difluoromethane （HFC-32）and 1,1,1,3,3-pentafluoropropane （HFC-245fa）, used as refrigerants, based on data published as openly available information. Only limited information on the toxicity of HFO-1234yf was available. HFO-1234yf did not show specific effects on acute, repeated exposure, cardiac sensitization and reproductive toxicity studies or particularly serious genotoxocity to living species. In developmental toxicity study of HFO-1234yf, pregnant rabbits died at 5,500 ppm and higher. In developmental toxicity studies of HFCs in rabbits, HFC-125 at 50,000 ppm, HFC-134a at 10,000 ppm and higher and HFC-32 at 50,000 ppm were maternally toxic, but not maternally lethal. Although this paper provides initial information on the toxicity of HFO-1234yf, further review of detailed information about the toxicity of HFO-1234yf is needed to adequately clarify its toxicity and assess the risks of this compound. Detailed information on toxicity studies of HFO-1234yf should be disclosed to ensure transparency concerning risk assessment of this compound.
