Sertraline is an antidepressant belonging to the class of selective serotonin reuptake inhibitors. It is frequently detected in aquatic environment because it cannot be completely degraded in the sewage plants. The effects and mechanisms of sertraline in mammals are well understood. However, its chronic effects in fish have been poorly evaluated. In this study, Japanese medaka (Oryzias latipes) was exposed to sertraline for 14 days, and the effects of sertraline on the fish brain were evaluated using a metabolomics approach. Exposure to 115 µg/L sertraline increased glutamate levels; however, this effect was suggested to be suppressed by several amino acids after 14 days of exposure. The effects in fish exposed to sertraline are unlikely to occur in actual aquatic environments.

Amine-based compounds, such as synthetic polyethyleneimines (PEIs) and biogenic polyamines, are promising CO₂ capture materials because of their high affinity for acidic gases. However, their potential toxicity in aquatic environments remains a concern. In this study, we compared the toxicity of three polyamines (putrescine, spermidine, and spermine) and of PEIs with average molecular masses ranging from 300 to 100,000 at concentrations of 1–1,000 ppm. Toxicity assays were conducted using planula larvae of a diploblastic species, the stony coral Acropora digitifera, and juvenile triploblasts, including zebrafish (Danio rerio), the Japanese big-eared Radix freshwater snail (Radix auricularia japonica), and embryos of the collector urchin (Tripneustes gratilla). Coral larvae exhibited high sensitivity to biogenic polyamines with a median lethal concentration (LC₅₀) of 22.2 ppm for putrescine, but relatively low sensitivity to PEIs (LC₅₀: 227.6–>1,000 ppm). In contrast, triploblastic animals were highly sensitive to PEIs (LC₅₀: 0.3–3.2 ppm), while being less sensitive to biogenic polyamines (LC₅₀: 294.9–389.7 ppm for putrescine) except for spermine. Notably, some PEIs exhibit toxicity even at concentrations below 1 ppm. These findings emphasize the importance of conducting organism-specific environmental toxicity risk assessments when amine-based CO₂ capture materials are used, particularly to avoid adverse effects on aquatic ecosystems.

We review the current challenges in the ecological risk assessment of ethylenediaminetetraacetic acid (EDTA) and cationic surfactants under Japan’s Chemical Substances Control Law. The complexity of EDTA toxicity assessment arises from its chelating properties, which influence metal bioavailability and ecological toxicity, making conventional assessment methods inadequate. Meanwhile, the toxicity of cationic surfactants is significantly affected by environmental factors, particularly organic matter content and water quality parameters. These variations pose substantial difficulties in achieving reliable toxicity assessments. While the Biotic Ligand Model (BLM) has been applied to address similar challenges in metal toxicity assessment, its effectiveness in evaluating EDTA and cationic surfactants has yet to be fully demonstrated. This paper examines existing evaluation methods, identifies their limitations, and proposes potential approaches for improving the reliability of risk assessments for these difficult-to-test substances.