シリコン化合物の突然変異原性に関する研究

抄録

For this proposed study, the silicon compounds, which are commonly applied on a refinery industry, after the administrations to mice were investigated on the mutagenicity in relation to distributions in various organs and excretions to urines in comparison with the chromium compounds. The results of these investigations were as follows: 1) The administration of silicon compounds such as silicon dioxides and sodium methasilicate existed a weak positive mutagenicity by the detection of "umu-lac" kit using Salmonella typhimurium TA1535/psk 1002 strain under the presence of S-9 mix. 2) The administration of hexavalent chromium compounds proved a potential positive mutagenicity, and, the trivalent chromic chloride also showed a weak positiveness. 3) Regarding the organ distribution of silicon and chromium compounds in the tissue of mice, there showed a high concentration in liver, kidney and blood at 180 minutes after the intraperitoneal injection of these compounds. The excretion of these compounds to urines was rapid, and, it seemed that the rate of accumulation of both compounds in these organs was low. 4) The workers in a refinery factory exhibited a significantly higher mutagenic activity in their urines than that of the controls. According to these results, the mutagenicity in urines was affected by the sort of occupations and smoking habitudes .However, the relationship between the mutagenic activities in urines and the excretion rates of silicon in urines was not obviously recognized.