Abstract
Objective: To investigate the relationships between the preoperative cognitive function and ICU-acquired delirium (ICU-AD) in patients who had undergone aortic surgery. Methods: The subjects were sixty-five patients who underwent elective aortic surgery. They were classified into the ICU-AD onset group and non-onset group. The data regarding the age, sex, BMI, medical history, mini-mental state examination (MMSE), type of operation performed, length of intubation, ICU days, the use or non-use of drugs such as sedative-analgesics, and the development of postoperative complications were compared between the two groups. Results: The incidence of ICU-AD was 27.6%. The preoperative MMSE in the ICU-AD group was significantly lower than that in the no ICU-AD group (25.1±3.9 vs 27.9±2.1, P<0.01). The preoperative MMSE was extracted as a predictor of ICU-AD by a logistic regression analysis. Furthermore, the cut-off value of the preoperative MMSE was 26.5 points [area under curve (AUC) 74%, 95%CI 0.580-0.891, P<0.01] by the receiver operating characteristic curve analysis of the preoperative MMSE. Conclusion: 26 or fewer points on the MMSE predicted the development of ICU-AD after aortic surgery.
