抄録
A similar aberrancy of α1-antitrypsis (α1-AT) was detected in 8cases; their serum α1-AT phenotypes (Pi) by acid starch gel electrophoresis seemed to be heterozygous of M and another one migrating more anodally. But these aberrant expression were suggested to be aquired. The common clinico-pathological abnormalities were in coagulation-fibrinolysis system. They were all diagnosed or strongly suspected to have disseminated intra-vascular coagulation.
568 sera with positive FDP (fibrin/fibrinogen degradation products) were tested for Pi. The same aberrancy of α1-AT were detected in 23.1% of them. The relationship between FDP levels and frequancies of aberrancy is statistically highly significant.
