抄録
D-penicillamine (D-PA) enhanced the plaque forming cell (PFC) response to sheep red blood cells (SRBC) in mice, when mice were immunized with 2-4×106 SRBC. However, when they were immun-ized with 4×108 SRBC, D-PA acted suppressively. The enhancing effect of D-PA on PFC response was observed when the drug was injected 2 hr after the immunization. Stress loading which was given by oral consecutive administrations of saline for 3 weeks or by restraint with the adhesive plaster from 3 days before the primary immunization reduced the IgE antibody formaion to egg albumn (EA) in mice. D-PA restored the reduced IgE antibody formation to EA after the secondary immunization. The mitogenic response to concanavalin A of normal rat spleen cells was slightly enhanced by D-PA at a concentration of 10 μM and inhibited at 100-10000 μM. However, the response of spleen cells of adjuvant arhritic rats, which remained essentially normal, was slightly inhibited even at 1μM of D-PA. These results suggest that D-PA shows an immunomodulatory activity on humoral and cellular immunity.
