炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
インドメタシン外用製剤の局所的抗炎症作用および経皮吸収
和田 靖史江藤 義則大平 明良木全 秀樹小出 高志石浜 洋水島 裕
著者情報
ジャーナル フリー

1981 年 1 巻 4 号 p. 511-514

詳細
抄録
A jelly-type ointment containing 1% indomethacin, ID gel, was prepared, and the anti-infla-mmatory effects and percutaneous absorption of ID gel were studied. ID gel inhibited carrageenin-induced paw edema concentration-dependently by topical application and showed significant effect at concentratin over 1%. ID gel inhibited inflammation only in the applied foot, but did not influence the edema of non-applied foot in car-rrageenin-induced edema experiments. It was shown that percutaneous absorption of indomethacin was markedly more into the exudate and muscle of the applied foot than those of non-applied foot and systemic blood. ID gel showed also anti-inflam-matory erects on adjuvant arthritis in rats and ultraviolet-induced erythema in guinea pigs.
著者関連情報
© 日本炎症・再生医学会
前の記事 次の記事
feedback
Top