炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
急性胃粘膜病変における内皮―顆粒球間相互反応とplatelet-activating factorの関与
黒瀬 巌末松 誠三浦 総一郎浅古 寛関塚 永一朴沢 重成永田 博司森下 鉄夫福村 大土屋 雅春
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1990 年 10 巻 2 号 p. 119-124

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Gastric microcirculatory disturbances induced by intermittent electrical stimuli (irritation) on the gastric artery produced acute gastric mucosal lesions in the rat stomach. In this experimental model, participation of platelet-activating factor (PAF) in granulocyte-endothelium interaction were evaluated.
Laser doppler flowmetry revealed that post-ischemic hyperemia was observed just after the irritation and the flow was significantly decreased after this hyperemic state. Mucosal tissue-type plasminogen activator (t-PA) activity was also elevated just after the irritation and still more increased thirty minutes after the stimuli. Moreover, both luminol-dependent chemiluminescence activity of regional blood sample and myeloperoxidase activity in gastric mucosa were remarkably increased thirty minutes after the irritation. A newly developed PAF-antagonist, CV-6209 attenuated the local fibrinolytic activity, granulocyte-mediated oxidative stress and the alteration of mucosal blood flow, and significantly diminished the gastric ulcer formation.
The present study suggests that PAF may cause the excessive fibrinolytic activity and granulocyte-mediated oxidative stress on mucosal microvasculature during acute gastric ulcer formation.
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