Abstract
On the process of the wound healing after operation, it has been known that some blood coagulation factors and plasma proteins had some important roles and significances. In addition, it has been known that protease-antiprotease system was closely related to the wound healing. In this paper, we examined the effect of urinastatin, an urinary trypsin inhibitor which was a polyvalent protease inhibitor, on the change of fibrinogen, factor XIII and fibronectin level in the circulating blood of rabbits after operation.
In administered group, 100, 000 units/ml of urinastatin was continuously injected to rabbits until 10 days after the operation. Level of fibrinogen in administered groups at 5, 6 and 12 day after the operation was significantly higher than that in non-admini-stered group (p<0.05) .
Activity of F. XIII in administered groups at 5 days after the operation was significantly higher than that in non-administered group (p<0.05) . Level of fibronectin in administered group was not significantly different from that in non-administered group.
From the result of increased level of fibrinogen, fibronectin and increased activity of F. XIII, it was suggested that administration of urinastatin gave the accelerating effect to the wound healing.
