抄録
To study the growth mechanism of jaw cyst, the authors investigated the arachidonic acid (AA) metabolites in cyst fluids. AA metabolites were separated and quantitated by high performance liquid chromatography (HPLC) .
The amount of leukotriene C4 (LTC4) and leukotriene B4 (LTB4) in the cyst fluid with inflammation was more than that without inflammation. On the contrary, the amount of prostaglandin D2 (PGD2) in the cyst fluid with inflammation was less than that wihtout inflammation.
To confirm the origin of leukotriens (LTs) in the cyst fluid, the authors measured the LTs produced by polymorphonuclear leukocytes (PMNs) obtained from peripheral blood and studied the effects of AA 861 and α-tocopherol. As a result, LTs could be detected in the PMNs suspension stimulated with Ca ionophore A 23187. Furthermore, the generation of LTs was completely inhibited by AA 861 and α-tocopherol.
These findings suggested that AA metabolites are important in the enlargement of jaw cysts.
