炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
白血球による血管内皮細胞障害に対する各種プロテアーゼインヒビターの効果
藤田 浩森田 育男室田 誠逸
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ジャーナル フリー

1991 年 11 巻 5 号 p. 501-502

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抄録
We examined whether or not some protease inhibitors prevent endothelial cell injury due to PMA-activated leukocytes. The effects of protease inhibitors on the cytotoxicity were determined by measuring the release of 51Cr from prelabeled cultured endothelial cells. We also examined the leukocyte produced active oxygen spPcics by measuring luminol-chenliluminescence.
Among the protease inhibitors tested, aprotinin and urinastatin decreased the endothelial cell injury in a dose dependent manner.
These data suggest that the protease inhibitors suppress priming effect of the leukocyte produced proteases on the endothelial cell injury induced by active oxygen species.
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