抄録
A single injection of monocrotaline (MCT) in rats, 60 mg/kg, could consistantly cause interstitial pneumonia 3-4 weeks after the injection. A preventive effect of cyclophosphamide, injected 4 times at 20 mg/kg each, on the rat pneumonia was studied in counting the 5-bromodeoxyuridine (BrdU) positive cells in the lung and measuring IL-1 and TNF levels in the culture supernatants of the bronchoalveolar lavage fluid (BALF) cells in the rats.
The CPA pulse therapy suppressed significantly the proliferation of BrdU positive cells in the lung and the levels of IL-1 (P<0.001) and TNF (P<0.001) in the cultured BALF cells. It was suggested that macrophage and their products, IL-1 and TNF, would participate to the MCT-induced interstitial pneumonia of the rats and CPA could suppress the function of the macrophage.
