抄録
Anti-rheumatic effects of UFT, in which tegafur and uracil were mixed at the molar ratio of 1 to 4, were studied experimentally and clinically.
Ratio of 5-FU concentrations in plasma, inoculated foot and non-inoculated of adjuvant arthritic rat after administration of UFT were examined in comparison with those of tegafur (FT) . Concentrations of FT in plasma, inoculated foot or non-inoculated foot after oral administration of FT or UFT (15 mg/kg) were nearly equal, whereas 5-FU levels on plasma, inoculated foot and non-inoculated foot after UFT administration were significantly higher than those of FT.
Clinical trial of UFT was carried out in 6 RA patients and the clinical response was evaluated according to the Lansbury index and other inflammatory parameters. The dose of UFT was 300 mg/ day.
Clinical response was observed in all 6 cases consisted of 2 marked improvement, 2 moderate improvement and 2 slightly improvement. Lansbury index and ADL showed a significant improvement as com-pared with pretreatment and UFT decreased the titer of RAHA and level of IgM.
The present study suggests that UFT may be useful in the treatment of RA.
