抽出法およびELISA法を組み合わせた尿中IL-6測定系の検討とメサンギウム増殖性腎炎患者における尿中IL-6濃度の臨床的意義

抄録

The simple extraction technique of urinary IL-6 was developed, so urinary IL-6 levels can be measured by enzyme linked immunosorbent assay (ELISA) method without the influences of non-specific reactions and/or inhibitors. The urinary IL-6 levels in active stage of MesPGN cases were higher than those of remission stage of MesPGN cases, healthy cases and other glomerular disease cases. And in remission stage of MesPGN cases, urinary IL-6 levels were same level as in healthy cases.
These data suggest that measurement of levels of urinary IL-6 is helpful for the diagnosis and evaluation of clinical activities of MesPGN.