抄録
We synthesized lecthinized superoxide dismutase (PC-SOD), recombinant human SOD covalently bound to a lecithin derivative. Next, we studied the pharmacological effect of PC-SOD and the mechanism of that.
PC-SOD inhibited the Forssman antiserum-induced respiratory resistance which is known to induce via actions of O2- at a dose of 100-1, 000 U/kg, whereas unmodified SOD did not.
PC-SOD was more effective at 2.8 fold in inhibiting the superoxide generation of neutrophils than unmodified SOD. Superoxide generation of neutrophils washed after incubation with PC-SOD for 1 hr was inhibited but not with unmodified SOD.
These data suggest that PC-SOD protects lung injury by Forssman antiserum in guinea pigs by binding to neutrophils. PC-SOD would be expected as a useful drug delivery system preparation for SOD.
