抄録
We newly prepared topical formulation for the mycophenolic acid in this study. Our preparation was effective enough to reduce the experimental allergic contact dermatitis induced by DNFB. Evaluation of efficacy of mycophenolic acid cream was performed as visual estimation on skin reaction and observation of tissues under the light microscope at 1, 2, or 3 days after the treatment. Skin damages of guineapigs treated with mycophenolic acid topical preparation were significantly improved compared to the group treated with vehicle only. This effect was continued up to 3 days. The degree of efficacy was better than betamethazone, especially in the early stage of treatment. Light microscope observation also supported these results. And it suggested that effect of mycophenolic acid cream would reach to dermis and epidermis layer. This novel topical preparetion of mycophenolic acid could be promising regime for the treatment of psoriasis and atopic dermatitis.
