抄録
There are some papers which report the increase of γδT lymphocytes in peripheral blood of the patients with Behçet's disease (BD) . However, there is no study which reports the analysis of infiltrated γδT lymphocytes in local tissue.
In this study the number of γδT lymphocytes and other T lymphocytes which infiltrated into large intestine of BD patients were counted using im-munoperoxidase staining. The results were compared with other inflammatory bowel diseases and normal controls. In BD the number of T lymphocytes increased in both intraepithelium and lamina propria. However, the ratio of γδT lymphocytes to CD3 lymphocytes decreased in the intraepithelium, while they increse in the lamina propria.
On the contrary, in ulcerative colitis and Crohon's disease, the number of T lymphocytes decrease in the intraepithelium, while they increase in the lamina propria. The proportion of γδT lymphocytes was the same as intestinal BD. The decreased ratio of γδT lymphocytes in BD large intestine might disturb the immunological surveillance and competence and play an important role in the pathogenesis of intestinal BD. The increased number of T lymphocytes in the intraepithelium seems to reflects the increase of αβT lymphocytes and this is the characteristics of intestinal BD.
