抄録
Early articular lesions were studied in four experimental animal models as follows; adjuvant arthritis in F344 rats, type II collagen-induced arthritis in DBA/1J mice, spontaneous arthritis in MRL/Mp-lpr/lpr (MRL/1) mice, and pristane-induced arthritis in DBA/1J mice.
Adjuvant arthritis: Acute inflammatory lesions started to develop 6 hours after elicitation. Chronic inflammatory lesions started to develop 3 days after elicitation.
Type II collagen-induced arthritis: Acute inflammatory lesions were started to appear by 6 hours and were seen dominant by 2 weeks after elicitation. Then the lesions started to diminish, and were replaced by chronic inflammation at 4 weeks.
MRL/1 mouse polyarthritis : Histopathological findings of the articular lesions started to develop by 6 weeks of age. Acute and chronic inflammation started at the same time.
Pristane-induced arthritis : IgG and IgM rheumatoid factor start to elevate their titer by 3 weeks and 6 weeks after elicitation, respectively. Joints lesions were noticed under microscope by 14 weeks. Acute and chronic inflammation were seen simultaneously.
Acute inflammation preceded chronic lesion in adjuvant arthritis and type II collagen-induced arthritis. Acute and chronic inflammation was seen simultaneously in MRL/1 mouse polyarthritis and pristane-induced arthritis. Immunological abnormalities preceded articular lesions in MRL/1 mouse polyarthritis and pristane-induced arthritis. Joint lesions preceded elevation of anti-type II collagen antibody in DBA/1J mice. Scientists have to pay much attention on differences in quality of arthritis in experimental animal models.
