炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
皮膚と活性酸素―酸化ストレスからの防御―
河野 善行宮地 良樹
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2000 年 20 巻 2 号 p. 119-129

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Cosmetics and Quasi-drugs will play new important roles in the aging and stressful society. We have proposed 3 clinical approaches, i.e., anti drying, anti-UV radiation and antioxidation to prevent the skin disorders and aging. Especially, the importance of anti-oxidation is discussed in this paper. The results of the investigation of the peroxidation on the skin surface using a CL-HPLC system, it was considered that singlet oxygen was the key active oxygen species on a human skin. We have clarified the reaction rate constants of the skin surface lipids and thiotaurine with singlet oxygen. Thiotaurine is known as a compound in a metabolism of sulfur containing amino acids in a mammal. We propose that the reconstruction and the reinforcement of the anti-oxidation mechanism in the living system will be useful new clinical approaches in the skin.

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© 日本炎症・再生医学会
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