炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
日本における視神経-脊髄型多発性硬化症
深澤 俊行菊地 誠志濱田 毅田代 邦雄
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2000 年 20 巻 3 号 p. 209-213

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The clinical features of MS in Japanese are said to be characterized by high incidence of optico-spinal MS (OS-MS), although the frequency of it has recently decreased. The term OS-MS is used to describe a subgroup of patients diagnosed with MS, in which the clinically determined lesions are confined to the optic nerves and the spinal cord. The OS-MS is characterized by a female preponderance, a later onset, a higher score of the expanded disability status scale of Kurtzke (EDSS), milder abnormalities on brain MRIs, higher sero-positive rates for some autoantibodies, and higher cell counts and protein levels in the cerebrospinal fluid, compared with conventional MS. The OS-MS is positively associated with HLA-DPB1*0501 allele, and the HLA prohile are different between OS-MS and conventional MS. Therefore, the OS-MS is immunogenetically as well as clinically a distinct subtype of MS.

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© 日本炎症・再生医学会
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