抄録
Superoxide dismutase (SOD) is produced in every human cells to prevent from the auto-oxidative damages by increasingly released oxygen-intermediates. We tried to treat with liposomal SOD 9 patients with intractable diseases, 3 PSS, 1 PM, 1 PSS+DM, 1 SLE+PM, 2 Behçet's disease and 1 paraquart intoxication. The patients were administered liposomal SOD at 2.5 mg/body 3 times in a week for one or two months. Two weeks after the administration, 4 patients with PSS and PM were significant improvement in their clinical symptoms such as palpitation and shortness of breath, and also % VC incresed to nearly normal range. An another patient with SLE plus PM who had chest oppression feeling due to myocardiopathy was also improvement. However liposomal SOD was not effective in a case of Behçet's disease. We think that liposomal SOD may be useful for intractable diseases, particularly when conventional therapies have failed.
