抄録
This recent study examined the effect of P-FN on CL response and O-2 production induced by stimulation of neutrophil mem-brane with zymosan, n-formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate, Ca2+ ionophore A 23187 and cytochalasin E. The relative intensity of luminol-dependent CL (LDCL) response was evaluated by ATP photometry, and O-2 production was spectrophotometrically measured by ferricytochrome C reduction in reaction mixtures with and without P-FN.
The results showed that both LDCL response and O-2 production of neutrophil were enhanced by the presence of P-FN in a dose-dependent manner. But P-FN alone could not induce LDCL response and O-2 production. From these results, it is suggested that P-FN may supplement respiratory burst of neutrophil.
