抄録
Objective: Venous thromboembolism (VTE) is a serious complication of total knee arthroplasty (TKA). The efficacy and safety of fondaparinux in the management of VTE was compared with that of aspirin. The dose-response relationship between 1.5 and 2.5 mg of fondaparinux was also evaluated.
Methods: The incidence of postoperative VTE was evaluated in 76 cases (62 patients) of TKA using 1.5 mg fondaparinux in 29, 2.5 mg fondaparinux in 17, and aspirin in 30 cases. Patients were examined for D-dimer 7 days after surgery; the postoperative blood loss was assessed from 1 to 7 days.
Results: The mean values of D-dimer were 9.66, 8.12, and 14.35 μg/ml in the groups administered 1.5 mg fondaparinux, 2.5 mg fondaparinux, and aspirin, respectively. The mean blood loss with 1.5 mg fondaparinux, 2.5 mg of fondaparinux, and aspirin was 167.8, 410.5, and 307.3 ml, respectively. The D-dimer values in the 1.5 and 2.5 mg fondaparinux groups were lower than those in the aspirin group.
Conclusion: Based on these findings, we infer that fondaparinux may effectively help prevent VTE following TKA. In addition, evaluation of postoperative blood loss demonstrated the safety of VTE treatment using 1.5 and 2.5 mg fondaparinux.
