原著
変形性膝関節症に対するエスフルルビプロフェンテープの有用性検討
キーワード:
knee osteoarthritis,
nonsteroidal anti-inflammatory drug,
esflurbiprofen,
patch,
comparative study
2019 年 38 巻 1 号 p. 23-27
詳細
2019 年 38 巻 1 号 p. 23-27
Objective: The purpose of this study was to investigate the usefulness of esflurbiprofen (SFP) tape which is a newly developed nonsteroidal anti-inflammatory drug (NSAID) tape for osteoarthritis of the knee (OAK) by comparing it with other established treatments, and to clarify its effective method of use.
Methods: Two clinical studies were conducted. In study 1, patients with OAK with existing use of tape and a visual analogue scale (VAS) value of 30 mm or more were included. The VAS improvement after four weeks was compared between the group that continued the existing tape (n=10) and the group that switched to the SFP tape (n=10), respectively. In study 2, patients with OAK who were untreated and had a VAS value of 40 mm or more were included. Intra-articular injection of hyaluronic acid was performed for six weeks in combination with either intra-articular injection of corticosteroid (n=10), an oral NSAID (n=10) or SFP tape (n=10), respectively. The change in VAS was then compared.
Results: In study 1, the VAS value was significantly improved by switching from the existing tape to the SFP tape. The amount of improvement of VAS was significantly larger in SFP tape group than in the existing tape group. In study 2, the VAS value improved significantly from start to end of the study in all groups. The amount of improvement in the VAS score was significantly larger in the SFP tape group than in the other groups, respectively.
Conclusion: SFP tape showed a strong analgesic effect, suggesting that it is useful either alone or in combination with intra-articular hyaluronic acid.
