抄録
Ceramic-coated metal implants were devised to improve the clinical results of total hip replacements. Alumina (Al2O3) ; titanium nitride (TiN), and hydroxyapatite (HAP) -coated stainless steel implants were inserted into the mid -diaphyseal region of the femurs of adult dogs. Titanium oxide (TiO2) and HAP-coated titanium implants were inserted into the distal epiphyseal region. Follow-up quantitative histological comparisons were performed for a period of up to 9 6 weeks. HAP-coated implants showed better biocompatibility than both stainless-and titanium-based materials. It would appear that HAP-coated titanium alloy is the most promising composite for use as the material of artificial joints.
We also investigated how bone reacted to HAP and Al2O3 in experimentally-induced osteoporosis, and bone was demonstrated to have a superior affinity to HAP than to Al2O3. So HAP-coated implants seem to be suitable for artificial joints in elderly patients.
