Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
Original Article
TET2 Mutation in Adult T-Cell Leukemia/Lymphoma
Kazuya ShimodaKotaro ShideTakuro KamedaTomonori HidakaYoko KubukiAyako KamiuntenMasaaki SekineKeiichi AkizukiHaruko ShimodaTakumi YamajiKenichi NakamuraHiroo AbeTadashi MiikeHisayoshi IwakiriYoshihiro TaharaMitsue SuetaShojiro YamamotoSatoru HasuikeKenji NagataAkira Kitanaka
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Keywords: ATLL, TET2, polymorphism
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2015 Volume 55 Issue 3 Pages 145-149

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Abstract

  Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7~12% of diffuse large B-cell lymphomas and 18~83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis. [J Clin Exp Hematop 55(3) : 145-149, 2015]

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© 2015 by The Japanese Society for Lymphoreticular Tissue Research
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