TET2 Mutation in Adult T-Cell Leukemia/Lymphoma

Kazuya Shimoda; Kotaro Shide; Takuro Kameda; Tomonori Hidaka; Yoko Kubuki; Ayako Kamiunten; Masaaki Sekine; Keiichi Akizuki; Haruko Shimoda; Takumi Yamaji; Kenichi Nakamura; Hiroo Abe; Tadashi Miike; Hisayoshi Iwakiri; Yoshihiro Tahara; Mitsue Sueta; Shojiro Yamamoto; Satoru Hasuike; Kenji Nagata; Akira Kitanaka

doi:10.3960/jslrt.55.145

Original Article

TET2 Mutation in Adult T-Cell Leukemia/Lymphoma

Kazuya Shimoda, Kotaro Shide, Takuro Kameda, Tomonori Hidaka, Yoko Kubuki, Ayako Kamiunten, Masaaki Sekine, Keiichi Akizuki, Haruko Shimoda, Takumi Yamaji, Kenichi Nakamura, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Mitsue Sueta, Shojiro Yamamoto, Satoru Hasuike, Kenji Nagata, Akira Kitanaka

Author information

Keywords: ATLL, TET2, polymorphism

JOURNAL FREE ACCESS

2015 Volume 55 Issue 3 Pages 145-149

DOI https://doi.org/10.3960/jslrt.55.145

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Abstract

　 Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7～12% of diffuse large B-cell lymphomas and 18～83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis. [J Clin Exp Hematop 55(3) : 145-149, 2015]

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