Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Review Article
The biology of the tumor microenvironment in DLBCL: Targeting the “don’t eat me” signal
Daisuke Ennishi
ジャーナル オープンアクセス

2021 年 61 巻 4 号 p. 210-215


Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma with biologically and clinically heterogeneous features. Recently, the tumor microenvironment of this disease has been recognized as an important biological aspect of tumor development and therapeutic targets. Recurrent genetic alterations play significant roles in immune recognition of lymphoma cells. In particular, novel genetic alterations promoting phagocytosis were identified, suggesting a potential therapeutic strategy targeting the “don’t eat me” signal.

© 2021 by The Japanese Society for Lymphoreticular Tissue Research

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