抄録
A case of cytophagic histiocytic panniculitis (CHP) occurring in a 15-year-old Japanese male is reported. The patient presented with typical fever, painful subcutaneous nodules, liver dysfunction, proteinuria, leukopenia, and coagulopathy shortly after sustaining a blunt trauma to the face, and died 6 months later due to severe hemor rhagic diathesis. Skin biopsy shortly after the onset revealed nonsuppurative lobular panniculitis with active proliferation of histiocytes in inflamed fat. Autopsy revealed systemic nonsuppurative panniculitis as well as proliferation of hemophagocytic histiocytes in inflamed areas and the reticuloendothelial system. Immunological studies suggest autoimmune etiology of CHP. Activation and proliferation of histiocytes may be caused by various lipid molecules released from inflamed adipose tissue, and coagulopathy of CHP may at least partly be caused by direct action of activated histiocytes on certain coagulation factors.
