抄録
The clinical features and therapeutic effects were investigated in 184 patients with extranodal lymphoma among 491 patients with non-Hodgkin's lymphoma (37.5%). Of the 184 patients, 85 had their primary lesions in the gastrointestinal tract, 37 in Waldeyer's ring, 24 in the paranasal sinus, 10 in the central nervous system, 5 each in the testis and skin, 4 in the thyroid, 3 each in the lung and salivary gland, 2 each in the adrenal, spleen, and muscle, and 1 each in the bone and mammary gland. Histopathology showed that the lymphoma was of low grade in 8 patients, intermediate grade in 169, and high grade in 7. There were 134 B cell lymphoma and 32 T cell lymphoma. A complete remission (CR) was achieved in 90.8% of the patients. The overall 5-year survival rate was 62.5% and the disease-free 5-year survival rate was 60.9%. Prolonged survival was achieved in patients having the primary lesion in Waldeyer's ring, the stomach, or the skin, while the outcome was poor for patients with the primary in the central nervous system or testis. Multivariate analysis showed that the factors associated with prognosis were LDH, stage, histological type, CRP, and bone marrow invasion. The site of the primary lesion was also a prognostic factor. More effective therapy is needed for the patients with their primary lesions in the central nervous system and testis.
